Loss of Dopaminergic Neurons and its Role in Parkinson’s Disease

Parkinson’s disease (PD) is described as a neurodegenerative disease characterized by akinesia (loss or impairment of voluntary movement), rigidity, tremors and difficulty walking. The clinical symptoms are thought to be mainly caused by the dopaminergic (DA) neurodegeneration, with other neurotransmitters such as serotonin or acetylcholine being partially responsible as well. Neurodegeneration is the deterioration of…